In one of the most important advances in modern medicine, a team of investigators isolated and purified insulin in a building that stood on this site. On May 17, 1921, Frederick Banting, a young surgeon, and Charles Best, a recent graduate in physiology and biochemistry, began a series of experiments on pancreatic secretions in an attempt to find a treatment for "diabetes mellitus." Working under the general direction of J.J.R. Macleod, an expert in carbohydrate metabolism, they developed a promising anti-diabetic extract. James Collip, a noted biochemist, then increased the purity and potency of the substance. With the first successful clinical test of insulin on a human diabetic on January 23, 1922, Banting, Best, Macleod and Collip ensured prolonged lives for millions of diabetics throughout the world.

Location

Two wall-mounted plaques are located on the west-facing wall to the left of the Macleod Auditorium entrance, north of the Medical Sciences Building, University of Toronto St. George Campus, 1 King's College Circle, Toronto

Themes

• Scientific and technological innovations